Master Course MOLECULAR & CELLULAR NEUROBIOLOGY
Faculty of Science - Radboud University, Nijmegen

 

INDEX

 INTRODUCTION CELLS AND WITHIN CELLS IN A NUTSHELL GENOMICS MOLECULAR BIOLOGICAL RESEARCH METHODOLOGY NEURODEVELOPMENT  
 

Welcome to the self-study part of the Master course Molecular and Cellular Neurobiology. The goal of this part is to give you the proper molecular and cellular background, and bring all students participating in the course Molecular and Cellular Neurobiology to a similar level that is necessary to follow the lectures accompanying this course. In view of the great diversity in the backgrounds of the (Cognitive Neuroscience Science, CNS) students participating in this course, this material covers items from a basic level to up-to-date Master level.

 

Contents
   
Chapter 1: Introduction
  From cells to the genome to proteins to function
Chapter 2: Cells and within cells
  Cells
      Neurons
      Glia
  Within cells
     Amino acids, Carbohydrates, Lipids and Nucleic acids
     Membranes and Membrane Proteins
     The Exctracellular Matrix
  DNA and genes
     More on DNA
     Epigenetics
     Transcription
     Noncoding RNAs
     miRNAs and the brain
  Translation

 

    Proteins, Protein Structure and Protein Analysis
     Protein folding in the cell
     Post-translational modifications of proteins
     Protein degradation in the cell - Autophagy 

 

    Protein secretion / Secretory pathway
  Receptor Mechanisms
     Ion channel receptors
     Tyrosine kinase receptors
     G-protein-coupled receptors
     G-proteins
     Transcription and signalling
     Transcription factor receptors
Chapter 3: In a nutshell: From genome to genetic variation to protein to disease
  From genome to genetic variation to protein to disease
  From genome to genetic variation to protein to disease (cont'd 1)
  From genome to genetic variation to protein to disease (cont'd 2)  
  From genome to genetic variation to protein to disease (cont'd 3)
Chapter 4: Genomics
  The genome
  Genomics research
  The Human Genome and HapMap Projects
  Functional Genomics
  Pharmacogenomics
  Genetic variations: SNPs and CNVs
  Genome-wide association studies (GWAS)
  Molecular networks
Chapter 5: Molecular biological research methodology
  Molecular biology and Recombinant DNA technology
  Techniques used in Molecular Biology
  Genetic transmission
  Genetic mapping
  Genomic and cDNA libraries
  Detection of DNA, RNA and protein
     Detection of RNA
     In situ hybridization
     PCR
     Microarray and RNA-seq analysis
     Bioinformatics - data analysis
     ChIP-chip/seq
  Generation of gene expression atlases of the central nervous system
  Gene transfer - transgenic animals
  Optogenetics
  Cloning
  Stem cells
  CRISPR-cas genome editing
Chapter 6: Neurodevelopment
  Neurodevelopment
  Neuronal outgrowth, axon guidance and axon guidance factors
   
   

For questions/remarks, contact Prof. Dr. Gerard Martens: 31-(0)24-3610564, 6th floor Radboud Institute for Molecular Life Sciences (RIMLS), UMC route 282, Geert Grooteplein Zuid 28, 6525 GA Nijmegen, The Netherlands; g.martens@ncmls.ru.nl