The idea that hydroxyl
groups of serines and threonines within the second transmembrane region would form a
hydrophilic pore has proven to be correct. The idea that hydroxyl
groups of serines and threonines within the second transmembrane region would form a
hydrophilic pore has proven to be correct.
Mutations of the serines and threonines to other amino acids has severe detrimental effects on ion conductances through the pore of the mutated receptor.